Metabolic - Epigenetic Crosstalk During Aging and Development.
Recent reports have indicated a close relationship between metabolism and epigenetic regulation and this cross talk is important in both disease and development. Several epigenetic enzymes utilize metabolites for their catalytic function and altering these metabolites can influence the function of these proteins. Furthermore, proper epigenetic control is critical for the maintaining metabolic homeostasis. My research involves understanding how dysregulation of metabolism-epigenetic cross talk contributes to aging and development.
Tran KA et al. (2015). Collaborative rewiring of the pluripotency network by chromatin and signaling modulating pathways. Nature Communication, DOI: 10.1038/ncomms7188
Tran KA et al. (2019). Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity EMBO, DOI: 10.15252/embj.2019101681
Role of Nuclear Compartments in Gene Transcription
Many compartments exist within the nucleus and have critical function in maintaining cellular homeostasis. Several of these nuclear compartments are altered during disease and aging. My research focus on understanding how these compartments regulate gene expression during aging and how proteins and DNA are recruited to these regions in response to environmental cues.